Fluoridation of drinking water and chronic kidney disease: absence of evidence is not evidence of absence

Fluoridation of drinking water and chronic kidney disease: absence of evidence is not evidence of absence

Nephrology Dialysis Transplantation, Volume 23, Issue 1, 1 January 2008, Pages 411, https://doi.org/10.1093/ndt/gfm663
03 October 2007


Ludlow et al. [1] only confirmed that our knowledge of the potential adverse effects of chronic low fluoride supplementation of drinking water on normal or diseased kidneys is insufficient. More than 60 years after water fluoridation, there is no high-level evidence as most published studies are small, have methological deficiencies or are otherwise flawed.

There are two areas of concern regarding the nephrotoxic potential of fluoride. A small and inclusive amount of research suggests that fluoridation of community water actually causes kidney disease. Kidney damage to tubular function and structure, and reduction in glomerular filtration rate occurred in residents of endemic fluoride areas [2] and anecdotal cases of fluoride intoxication [3] suggested a causal relationship between fluoride intake and renal failure. Ludlow et al. are correct that no evidence of an increased frequency of kidney disease or tubular dysfunction has been observed in early US epidemiological studies, comparing non-fluoridated areas (0.3 mg/dl) to up to 8 mg/l fluoride in drinking water. None of these studies described renal function of the participants or serial changes in simple urinalysis. Of interest, the data of a recently published study suggested that drinking water contains fluoride levels over 2.0 mg/l—half of the fluoride concentration deemed safe by the US Environmental Protection Agency (EPA)—could cause damage to renal tubular structures in children. This conclusion is based on an investigation of ……… Read more



The influence of fluoride in drinking water on stone formation was studied in animals and in “in vitro” cristallization experiments. In male Wistar rats fluoride inhibits ethylenglycol induced calcification of the kidneys and stone formation. The in vitro results performed in synthetic urine exhibited a dose-dependent delay of cristal growth.

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